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Because bupropion hydrochloride contains the same active ingredient as the antidepressant bupropion, the FDA advises talking to your healthcare provider about the risks of treatment with antidepressant drugs

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Lastly, methodologies for measuring these endpoints, including techniques and timing of biomarker assessments, varied across studies

Thirdly, although our analysis identified population-level associations, observational design inherently limits causal inference, and linear trend assumptions (such as EAPC) may oversimplify complex temporal dynamics affected by sudden policy shifts