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Our previous mouse model and in vitro studies revealed that PRMT6 exerts a negative effect on CS-induced pulmonary inflammation through H3R2me2a, while overexpression of PRMT6 inhibits CS-induced inflammation [51, 52]

To determine doseresponse relationships, the association between smoking pack-years and cortical thickness was tested and then repeated, while controlling for a comprehensive list of covariates including, among others, cognitive ability before starting smoking

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