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Potential therapeutic targets of anti-HCC There are lots of potential targets that were related with MDM2p53 axis dysfunction that can be considered to exert anti-HCC properties, all of which have been found to be abnormally changed in tissues of HCC patients, and are correlated with favorable/unfavorable HCC outcomes (Table 1)

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Thus, the levels of the pro-inflammatory cytokines TNF, IL-1 , IL-6, IL-12, and IL-13 were elevated, whereas the levels of the anti-inflammatory cytokine IL-10 were reduced, in the lungs of exposed mice [115, 116]

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Absorption : The total nicotine absorbed is highly dependent on how long the pouch is held in place, the pH level of the pouch (which affects bioavailability), and the users saliva production