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In today's context, they often mean different things

Study of the mechanisms of cigarette smoke gas phase cytotoxicity

Comparison of the toxic, hypnotic and irritating properties of eight organic solvents

Currently, it is estimated that nearly 8 million people die each year due to tobacco-related illnesses, which costs the global economy US $1.4 trillion annually.1 An efficient and systematic surveillance mechanism to monitor the epidemic is one of the essential components of a comprehensive tobacco control program

But in suggesting that there is a neurophysiological basis for the observation that nicotine use can increase the reinforcing properties of alcohol, it may also underscore that tobaccos harms may extend well beyond cancer and heart disease, and that the toll it has taken may go well beyond the 100 million people it is estimated to have killed in the 20th century alone.