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Medications that can produce a serotonin syndrome when combined with MDMA include commonly prescribed antidepressants, such as selective serotonin reuptake inhibitors, serotonin, and noradrenaline reuptake inhibitors, monoamine oxidase (MAO) inhibitors, antimigraine triptans, some opioid analgesics (fentanyl, tramadol, and dextromethorphan), and the antidepressant buspirone (Table 2) 29 - 31

Additional country analyses of the same data have indicated that the overall decreases in alcohol use found across Europe mask increases in consumption reported by previously heavy drinking individuals [41]

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