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Frataxin deficiency increases the expression of the mitoferrin proteins as well as transferrin receptor 1 (Tfr1) which mainly function to import iron, revealing a potential cause of mitochondrial iron overload ( 5 Metabolic Control of Heme Synthesis It has been established that heme synthesis must be coupled with metabolic requirements to prevent toxic accumulation of heme and its intermediates

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Study selection and data extraction All articles found by the search strategy will be exported to the Rayyan QCRI application for initial selection by considering their titles, abstracts, and keywords