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doi: 10.1038/nature08530 95 PompuraSLWagnerAKitzALaPercheJYosefNDominguez-VillarMet al

The analysis of 4887 participants treated with tirzepatide and 2,328 participants in the control groups identified 142 participants who developed at least one MACE-4p (inclusive of cardiovascular mortality, myocardial infarction, stroke, and hospitalization for unstable angina) and confirmed the cardiovascular safety with an hazard ratio (HR) of 0.80 (95% CI 0.571.11) for the comparison between tirzepatide and controls

GST pulldowns or immunoprecipitation are the most common version of this type of experiment, but you can perform analogous isolation experiments with other protein tags including his-tags and strep-tags (Figure 7)

COX-2: The Inflammatory State COX-2 is inducible and is expressed in activated lymphocytes, polymorphonuclear cells, and other inflammatory cells