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NRF2 is tightly regulated at different levels by epigenetic modifications such as OS, inflammation, and different forms of stress [148], and has regulatory functions in mitochondrial biogenesis and cellular energy metabolism [149]

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Various transporter-mediated or receptor-mediated transporting processes at the BBB responsible for endogenous molecules, such as transferrin, insulin, low density lipoprotein (LDL), glucose, glutathione, etc., have been targeted for developing brain targeting agents

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However, it is unsafe for pregnant or breastfeeding women, as it can cause serious congenital disabilities and developmental issues in babies