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Based on the federal notice and prior regulatory filings, the substances under consideration are drawn from the broader list of peptides that were placed on the Category 2 restricted list beginning in 2023

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Prolotherapy for AC Joint Separation: How It Works In the context of AC joint separation, prolotherapy targets the damaged acromioclavicular and coracoclavicular ligaments , which are essential for maintaining clavicle stability

Theyre widely available over the counter or through prescriptions and are usually cost-effective

They do not provide enough evidence to define an accepted clinical use