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The mechanism involves attraction of immune cells and mesenchymal stem cells to wound sites, along with stimulation of glycosaminoglycan production and decorin synthesis, both of which are critical for proper extracellular matrix assembly

Salvador E, Burek M, Forster CY

Studies document effects on 31.2% of human genes (approximately 4,000+ genes) with 50% expression change, suppressing RNA production in 70% of 54 genes overexpressed in metastatic colon cancer

This is because overuse can lead to digestive issues, affecting absorption and causing oxidative stress

However, ABT-737 has limited oral bioavailability and aqueous solubility