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Chronic nicotine exposure increases dopamine D2 receptor binding in the ventral striatum, lowering the reward threshold and rendering the nucleus accumbens more responsive to cocaine and amphetamines in subsequent exposures

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Ni Y, Shi G, Qu J (2020) Indoor PM2.5, tobacco smoking and chronic lung diseases: a narrative review

20 The second model is known as the 5 Rs. These are: relevance to the patient