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In 2021, Europol detected and reported 74 illegal cigarette factories in the EU, up from 47 in 2018

Responses can vary based on the presence of mental disorders, use of other illicit substances, or co-occurring conditions such as chronic pain

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In some cases, other markers like anabasine and nornicotine may be tested to help distinguish between nicotine from tobacco and nicotine from replacement therapies or other sources