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Front Immunol

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Under the agencys current premarket review compliance policy, which it has recently indicated it may be reconsidering for certain types of e-cigarettes, 5 manufacturers of deemed noncombustible tobacco products such as ENDS that were on the market when the Deeming Rule went into effect have until August 8, 2022 to submit PMTAs, and can remain on the market through that date and pending FDA review

Understanding the role the parthanatos pathway plays in HBE cell response to smoke exposure is therefore important before contemplating interventions to influence its activation as a strategy to treat smoke-related lung disease

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