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Conclusion Alopecia areata is a complex autoimmune disorder that can significantly affect an individuals quality of life

A missense mutation (G2019S) within LRRK2 modifies -synuclein pathology in a mouse PD model and increases kinase GTPase activity to inhibit autophagy and augment the pro-inflammatory response in mouse models of colitis (Takagawa et al., 2018

Each category demands a different level of clinical confidence, and conflating them does a disservice to patients trying to make informed decisions about their healthspan

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