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Nicotine, the chief component of tobacco and a highly addictive substance, also act as a gateway to other drugs by changing the brain through the release of dopamine and the formation of additional nicotine receptors

[56] For comparison, the non-Mori population of the North Island increased from 17,371 to 193,047 during the same period

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Both substances affect brain chemistry in different ways, and their interaction can lead to side effects like increased anxiety, drowsiness, impaired coordination, and in rare cases, serotonin syndrome

doi: 10.1186/s12903-024-05018-7 50