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No explanation for the decision was given, and CNN reported that there were no dissents

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negative feedback on LH release High dose : inhibitory feedback on GnRH release from the hypothalamus Contraindications to Combination Oral Contraceptive Use Pregnancy History of Thromboembolism History of Cardiovascular or Cerebrovascular Disease Smoking & age of 35 years Breast Cancer Hepatoma Undiagnosed Vaginal Bleeding Uncontrolled Hypertension Depression Reference: Chrousos GP (2015): The Gonadal Hormones & Inhibitors (Chapter 40)

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These subtypes are also responsible for cervical, penile, anal and vaginal cancer