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Among the other drug efflux ATPase genes previously reported to contribute to cisplatin resistance ABCG2, ABCC2, ABCA1 , and ABCC1 were significantly up-regulated in at least one cell line (Figure S3cf), while ATP7B was unchanged after exposure to e-cigarette aerosol extract (Figure S3g)

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Countries including the United Kingdom 18 , China 19 , Spain 20 , Bolivia 21 , and the Netherlands 22 have strengthened tobacco control policies, implementing evidence-based strategies such as tobacco taxation, plain packaging with health warnings, and comprehensive bans on advertising, promotion, and sponsorship

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