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The good feeling that it brings usually leaves smokers resorting to it as a solution to their physical, emotional, and mental challenges

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Since nicotine is rapidly eliminated from the brain, its effects on pain reduction become more complicated under chronic exposure conditions, where the impacts of nicotine withdrawal symptoms and nAChR desensitization outweigh the analgesic effects of absorbed nicotine, thereby resulting in elevated pain sensitivity [9] (Fig

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