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At the same time, addiction is still portrayed as a moral failing, as though nicotine dependence, even without smoke, were one of the gravest sins

Other evidence of the possible irritant and inflammatory effect on cells comes from an in vitro study in which the exposure of tracheobronchial cells to electronic cigarette nicotine-free vapours was related to a concomitant increase in interleukin-6 and interleukin-8 cytokine production with a dose-dependent response and direct evidence of endothelial dysfunction.84 The association with inflammation and endothelial dysfunction is most likely mediated via nitric oxide pathways

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20 (Suppl 1): 10i16

See the table below for an assessment of the potential impact of tobacco retailer license fees on the additional cost of a pack of cigarettes