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"Origins of the WHO Framework Convention on Tobacco Control"

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doi: 10.1136/tobaccocontrol-2016-052934

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Conclusion Studies show that behavioral treatments particularly in adolescents are effective, whereas pharmacotherapies have only marginal success ( Nicotine dependence over time can result in neuro-plastic changes in the brain (163), and therefore there is a possible concern for nicotine replacement therapy use during adolescence, which is that nicotine can change the neurodevelopmental trajectory