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One big thing that can get in the way is tobacco use

Finally, code-based smoking status assignment is a comparable covariate to text-based smoking status for genetic association studies.Our results support the use of ICD-9 tobacco use codes for identifying smokers in a clinical population

FDA used a similar line of reasoning in developing the tobacco rule when it concluded that banning tobacco products under the FFDCA's drug and device provisions was not an option

The American Pharmacists Association passed a policy in 2019 stating support for tobacco-free pharmacies, but thousands of pharmacies currently ignore the recommendation

3% nicotine equals roughly 35mg/mL, or about 23mg of total nicotine per pod