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While Rheumatoid arthritis can be hereditary, studies show that smoking can increase risk and also worsen the symptoms
Note that while sensitivity analyses 1, 2 and 5 use the fitted regression coefficients from the main model, sensitivity analyses 3 and 4 use alternative regression coefficients, either those fitted to the data from the studies with well-defined groups or those using the alternative RR estimate for individuals using snuff/snus
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