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Description

Hypoxiainducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype, 2017

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In addition to the relevance of POP conjugation cited previously, hyperglycemia and hyperinsulinemia appear to directly inhibit glutathione synthesis (GCL), and the increased production of reactive oxygen species which accompanies diabetes further depletes GSH levels

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Mutations in homocysteine metabolism genes increase keratin N-homocysteinylation and damage in mice

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GSH GSSG

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