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Thus, CHAC1 serves a dual role: it preserves mitochondrial function by ensuring a cysteine supply under nutrient stress, but it also facilitates ferroptosis by maintaining ETC activity, highlighting its potential as a therapeutic target in cancer treatment ( 4.4 Apoptosis CHAC1 is implicated in apoptosis, particularly in the context of ER stress and UPR

The gut microbiome is an important regulator of GABA synthesis, with Lactobacillus brevis being the most effective enteral flora generator of GABA (165)

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