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Smoking is not a leading risk factor for thoracic aortic dissection high blood pressure, family history of cardiovascular disease, connective-tissue disorders (Marfan, Loeys-Dietz, Ehlers-Danlos) and bicuspid aortic valve are the main drivers

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These changes, still traceable centuries after death, offer a new method for categorizing skeletal remains and gaining deeper insights into the long-term health effects of tobacco use on past populations