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Polymorphisms in CYP2A6 have been associated with racial and genetic differences in metabolism of nicotine, but it is unclear if these impact smoking-related pancreatic disease (77)

In smokers, a single dose of the xanthine oxidase inhibitor allopurinol restores the acetylcholine-induced endothelium-dependent relaxation response in forearm arteries to nonsmoker levels but does not affect the endothelium-dependent relaxation response in nonsmokers [73]

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