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27 Tissue Distribution Experiments To investigate the tissue distribution of panduratin A, a total of 16 rats were randomly divided into four groups (n=4 per group) depending on the time point of sacrifice including 0 (pre-dose), 0.25, 1, and 4 h after dosing

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When injected subcutaneously, the peptide reaches peak plasma levels within 1-3 hours and is cleared relatively rapidly, likely through peptidase degradation and renal filtration