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In addition to pathogenic microorganisms in the biofilm, genetic and environmental factors has enormouse influence on development periodontal disease.Tobbaco use is one of the modifiable risk factors and has enormous influance on the development, progres and tretmen results of periodontal disease

Available at: Accessed 13 Aug 2025 Thornley S, McRobbie H, Lin RB et al (2009) A single-blind, randomized, crossover trial of the effects of a nicotine pouch on the relief of tobacco withdrawal symptoms and user satisfaction

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