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Many studies have revealed that immune responses mediated by Th1 and Th17 cells play an important role in CD [3840], and that nicotine, a major component of tobacco smoke, can worsen the trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice with an increased percentage of Th17 cells [41]

If you already enjoy fragrances such as Back to Black or Tobacco Vanille, this scent will likely feel immediately familiar and comfortable, perhaps even luxurious in its refinement