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Sordo L, Du A, Sandadi V et al (2025) Leptin levels are associated with body mass index and Alzheimers disease in Down syndrome

doi: 10.1038/nrendo.2010.215 63 XavierMJRomanSDAitkenRJNixonB

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The lessons learned from astrocyte-targeted strategies provide a natural transition to examining microglia, whose dual role as immune defenders and potential drivers of pathology makes them equally compelling therapeutic targets (Figure 5)

TJs, composed of claudins, occludin, junctional adhesion molecules (JAMs), and the zonula occludin (ZO) family, are believed to regulate vascular paracellular transport by forming a high-resistance electrical barrier [17]