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In the present study, the upregulated arginine biosynthesis and arginine and proline metabolism in the HN group, suggested that compared to low-nicotine cigarettes, high-nicotine cigarettes may have a larger effect on arginine biosynthesis and metabolism

Details of covariate adjustment used in each study are provided in Supplementary file Table 5

High-quality prerolls release distinct, strain-specific aromas when the packaging openscitrus notes for sativas, earthy undertones for indicas, or complex combinations in hybrids