The Safety of Glutathione for G6PD Deficiency The question of safety often arises because people with G6PD deficiency are told to avoid "oxidizing agents." Since glutathione is an antioxidant, it is the opposite of an oxidizer
Histone deacetylases (HDACs): evolution, specificity, role in transcriptional complexes, and pharmacological actionability
activation of PI3K/AKT downstream pathway driving synaptogenesis and anti-apoptotic effects in hippocampus Regulatory status: not approved by the FDA or EMA
These include decreased drug transport, increased cellular detoxification because of increased glutathione (GSH), changes in DNA repair involving increased nucleotide excision repair and/or loss of mismatch repair, increased tolerance of DNA adducts, and alterations in the apoptotic cell death pathway (Andrews and Howell, 1990
Those compensatory mechanisms depend on the NAD(P)H-mevalonate pathway that synthesize ubiquinol