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For some smokers, combination therapies using multiple types of NRT, NRT with bupropion, NRT with counselling, and NRT with bupropion and counselling may be even more effective than using a single cessation method

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The result: Semi-sweet, smooth, honeyed pipe tobacco dusted with cinnamon

N Engl J Med 2013;368:341-50.ArticlePubMed 3

For non-smokers or those not accustomed to nicotine, this can result in a noticeable tingling or "shock" running through your body, signaling your first real encounter with nicotine 3