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This is not altogether unprecedented, as other groups using similar non-acute exposure regimens have reported a similar lack of cytokine elevation in bronchoalveolar lavage fluid (Larcombe et al., 2017), and alveolar macrophages from smokers exhibit a blunted response to pro-inflammatory stimuli (Chen et al., 2007)

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The study, published Wednesday in the Journal of the American Heart Association, found smokers were more likely than nonsmokers to have a heart attack or stroke in middle age with no prior indication they had cardiovascular disease sometimes with fatal consequences