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Participants were excluded if they (1) had cardiovascular diseases, (2) had used addictive drugs other than nicotine, (3) current or past history of medical or psychiatric illness, diagnosed by the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th edition, Axis I Disorders (SCID)

The Tobacco Products Directive 2014/14/EU (TPD) introduced new rules for nicotine-containing e-cigarettes and refill containers (Article 20) which ensure minimum standards for the safety and quality of all vape products

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