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Other related diseases such as fontal temporal dementia (FTD) appears to have overlap both with AD and ALS, and is commonly related with TDP-43 and C9ORF72 mutations of ALS (Warren et al., 2013), although there is evidence for TDP-43 involvement in AD, it appears to take a different progression pattern compared to ALS and FTD (Meneses et al., 2021), which suggests distinct disease mechanisms at play

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[DOI] [PubMed] [Google Scholar] 128.Du K., Wu X., Ji X., Liang N., Li Z

At the same time, long-term safety data for SRT2104 remain insufficient, and the impact of other potential side effects requires further evaluation [46-48]

doi:10.1177/2047487320909065