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Because of its metabolic role, NNMT is expressed in liver, adipose tissue, kidney, and other tissues

The mean age of dementia onset was 54.5

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Explored as a possible aid for recovery and lean-mass preservation in frail or catabolic populations, though a Merck-sponsored Phase 2b trial in elderly hip-fracture patients (Adunsky et al., 2011, Archives of Gerontology and Geriatrics, PMID 21067829) was halted early over a cardiac safety signal rather than demonstrating a clear functional benefit

Bercu JP, Galloway SM, Parris P, Teasdale A, Masuda-Herrera M, Dobo K, et al