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Using a statistical approach known as mediation analysis, the researchers determined the sequence of events: genetic predisposition leads to smoking, which leads to decreased brain volume

Because e-cigarettes are relatively new to the consumer market, they remain largely unregulated

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TABLE 1 CAGE Questionnaire Modified for Smoking Behavior* Examples of actual patient responses to these questions include the following: C ut down: I wanted to quit smoking, but I couldn't do it, so I switched to a low-tar cigarette. A nnoyed: Last week, my granddaughter said to me, Grandma, I wish you would stop smoking, and I snapped at her, Well, I'm old enough to smokeare you? G uilty: I should have stopped smoking long agomy family wouldn't have to suffer on my account like this if I had. E ye-opener: I smoke my first cigarette before my feet hit the floor. Experience has shown the CAGE questionnaire to be nonthreatening

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