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Moreover, an interval timing behavioral test in this model reveals a sex difference in that female mice show delayed anticipatory respondings and lower response amplitudes compared to males, suggesting differential incentive motivation between sexes in these AD mice ( The above observations suggest that apathy-like behaviors might be associated with both A and Tau pathologies

This effect arises because of the nonlinear inhibition of GCL and GS by GSH [Figure 2B]

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