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Cerebral pharmacokinetics and microdialysis To confirm that a peptide actually reaches its cerebral target, microdialysis remains the reference tool: Principle : insertion of a semi-permeable membrane probe in a target region (hippocampus, frontal cortex)

Chitimus et al

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Mechanism: hepatocyte growth factor (HGF) / c-Met Dihexa activates the HGF / c-Met pathway in neurons, inducing synaptogenesis (formation of new synapses) and dendritogenesis