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Another study on human organotypic oral epithelial cultures showed that IQOS, compared to CS, yielded less cytotoxicity (significant after 48 h post-exposure), secretion of proinflammatory mediators, and gene expression perturbations related to apoptosis, necroptosis, senescence, xenobiotic metabolism, and oxidative stress 58

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While less expensive and more widely available, machine-made cigars generally offer a simpler flavor profile and are often less refined than their hand-rolled counterparts

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