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Furthermore, a recent extensive cohort study involving over 33,000 GLP-1 RA users diagnosed with diabetes over a 9-year period indicated no significant increase in pancreatic cancer risk associated with GLP-1 RA use, as evidenced by an HR of 0.50 compared to basal insulin [60]

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Furthermore, this HG concentration was associated with a sustained increase in ROS generation (up to 96 h), suggesting it effectively induces oxidative stress, partly due to the simultaneous disruption of the antioxidant defense system [23]

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In addition, Ferrostatin and Liproxstatin-1 were able to inhibit oxidative stress via restoring GPx4 activity