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Three main mechanisms leading to hyperhomocysteinemia are these: (1) an inhibition of the homocysteine remethylation pathway dependent on folate or cobalamin deficiency, on the C677T mutation of MTHFR, or on the functional deficiency in methionine synthase

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10.1158/1535-7163.MCT-09-0290 43 KoeberleA.PollastroF.NorthoffH.WerzO