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Consistent with a protective effect of vitamin therapy, higher plasma homocysteine levels were associated with an increased risk of new cardiovascular events in normohomocysteinemic but not in vitamin-treated hyperhomocysteinemic subjects

Continuous use without breaks can reduce receptor sensitivity and potentially cause copper dysregulation

The subjects were young (average age 27), lean (average body mass index 24), and physically fit

Full details of the interactions are shown in Supplementary Fig

The study was conducted in three phases: (i) participant screening and selection, (ii) dietary intervention, and (iii) post-intervention metabolomic analysis