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96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis
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This is often closely intertwined with mast cell activation syndrome (MCAS), where accumulated toxins and chronic oxidative stress cause mast cells to become hyper-reactive, constantly degranulating and releasing histamine and other inflammatory mediators into the bloodstream
