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For chelators, such as DFO, which has a short plasma half-life and therefore requires frequent doses, the IN route provides a safe and efficacious delivery method with higher patient compliance

39 proteoforms deriving from 25 parent genes were significantly associated with cognitive resilience and frailty, including proteoforms of VGF, SST, CCK and CHGA/B

doi:10.3389/fphar.2025.1551843 Wang X, Liu B, Xu Q, et al

Protein-Derived Acetaminophen-Cysteine Can Be Detected After Repeated Supratherapeutic Ingestion of Acetaminophen in the Absence of Hepatotoxicity

There are also indications of an upregulation of ABCG2 in correlation with an inflammatory marker in human brain tissue 49