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ISSN 1420-3049

These alterations, along with elevated levels of the epidermal growth factor receptor [EGFR] and decreased P 53 , P 16 , and Rb- gene expression, are crucial players in developing squamous cell carcinoma [54]

Glutathione suppresses tyrosinase in three ways: direct inhibition through chelation of copper, interference with the transfer of tyrosinase to premelanosomes, tyrosinase inhibition indirectly by antioxidant effect

Oxidative stress is regarded as a common feature of neurodegenerative diseases, which leads to telomere attrition, the excessive phosphorylation of tau protein, increased A oligomers, and immunologic derangement, further mediating the senescence of these brain cells [138]