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Due to the distinct position of the conjugated N-terminal lipid between Cagri-CTR and Cagri-AMY 1 R, we also determined a structure of CTR-Gs in complex with an analogue of Cagri that lacked the lipid modification (CagriBB) to interrogate the contribution of the acylation to the conformation of Cagri-CTR complex

[86] In addition to a role in intestinal absorption, RFC is expressed in virtually all tissues and is the major route of delivery of folate to cells within the systemic circulation under physiological conditions

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