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This vascular thrombo-inflammatory state not only drives local endothelial dysfunction, but also intersects with systemic metabolic regulation, creating a feedback loop that links neutrophil activation to tissue-level metabolic stress

Therefore, formulating SLNs with chitosan can protect them against the acidic gastrointestinal medium and enhance their transmucosal delivery, consequently increasing the effective concentration of encapsulated drugs at the absorption site

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These supplements come in the form of oral supplements and injections