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The pathogenesis of BO is not well-understood although genetic and environmental factors play significant roles

actual costs vary by pharmacy and insurance (GoodRx)

Acceptable sterility levels are based on applicable standards that define therapeutically acceptable otic formulations or compositions, including but not limited to United States Pharmacopeia Chapters et seq

Reduced inflammatory cytokine activity, improved microvascular integrity, and beneficial effects on pain modulation through peripheral and dopaminergic mechanisms are among the reported effects in animal studies

They modulate ROS levels, restore immune homeostasis, and remodel the local inflammatory microenvironment, either as monotherapy or in combination with conventional agents